5 Essential Elements For phenobarbital sodium route of administration
5 Essential Elements For phenobarbital sodium route of administration
Blog Article
pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers could lessen sufentanil amounts and efficacy, maybe precipitating withdrawal syndrome in clients which have created physical dependence to sufentanil. Discontinuation of concomitantly used CYP3A4 inducers may possibly boost sufentanil plasma concentration.
pentobarbital will reduce the extent or effect of ibuprofen by impacting hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unknown.
pentobarbital will decrease the level or effect of docetaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Mysterious.
pentobarbital will decrease the level or effect of verapamil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Watch Closely (one)pentobarbital will lower the extent or effect of mestranol by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the level or effect of pantoprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.
Particular affected person populace: Dosage ought to be lowered while in the elderly or debilitated due to the fact these sufferers can be much more delicate to barbiturates. Dosage needs to be decreased for individuals with impaired renal function or hepatic illness.
Watch Carefully (1)pentobarbital will decrease the level or effect of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to some minimize in fentanyl plasma concentrations, not enough efficacy or, potentially, growth of a withdrawal syndrome in a very patient who has created Actual physical dependence to fentanyl. After stopping a CYP3A4 inducer, as being the effects check here of the inducer drop, the fentanyl plasma concentration will increase which could increase or lengthen both of those the therapeutic and adverse effects.
pentobarbital will reduce the extent or effect of montelukast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unfamiliar.
pentobarbital will reduce the level or effect of vincristine liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
pentobarbital will lower the extent or effect of etonogestrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
fentanyl transmucosal and pentobarbital both improve sedation. Keep away from or Use Alternate Drug. Limit use to individuals for whom alternative remedy solutions are insufficient
pentobarbital will minimize the extent or effect of tofacitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Loss of, or reduced response to tofacitinib may possibly come about when coadministered with strong CYP3A4 inducers
States began using it for executions in 2011, due to a lack of sodium thiopental, which was Formerly used in executions––together with pancuronium bromide and potassium chloride.